(Level A) $78,544 to $105,611 or (Level B) $111,031 to $131,335 per annum plus an employer contribution of 17% superannuation applies.

Fixed term, full time position available for 24 months.

The 3D Chromatin Organisation Lab (PI Dr Joanna Achinger-Kawecka) is seeking a postdoctoral researcher to work on the interphase of chromatin structure, epigenetics and transcriptomics. The applicant should have experience in epigenetics and/or chromatin field, a good publication record and be motivated to independently shape their own projects.

The Lab’s research focuses on understanding the role of 3D chromatin alterations in driving cancer development, progression and treatment resistance. We use cutting-edge methods (multi-omics, single-cell, genome editing as well as various pre-clinical model systems) to study the interplay of the 3D chromatin, epigenome and transcriptome in cancer. We use hormone-dependent cancers as a model system for experimental design aimed at increasing our understanding of the cancer biology and to accelerate the development of new therapies.

About the project:

The successful candidate will use cutting-edge experimental and bioinformatics approaches to understand the dynamic and specific 3D chromatin organization in cancer cells and its interaction with non-coding elements and transcription factors.

The applicant will implement a number of new multi-omics approaches, including different chromosome conformation capture-based methods (Hi-C, Capture Hi-C, HiChIP, Pore-C) and the development of high-throughput single-cell and spatial 3D genome, epigenome and transcriptome profiling technologies. The applicant will have on-site access to core equipment and facilities for epigenetics studies, such as high-performance computing, NGS sequencing, imaging, tissue culture, animal facility and flow cytometry.

Your responsibilities:

• Implement and optimize cutting-edge genomics technologies (e.g. Hi-C, RNA-seq, CUT&RUN/Tag, ATAC-seq, WGBS, Nanopore)
• Analyse high-throughput next-generation sequencing (NGS) data
• Develop novel methods for data integration across multi-omics datasets
• Supervise student projects at Honours, MSc and PhD level
• Write reports and research articles, as well as grant proposals, and regularly participate in domestic and international conferences and workshop to present your own work

To be successful at the Level A position you will need:

• PhD in relevant biological subject (molecular biology, biochemistry, genetics or related) or near completion
• Laboratory experience in a wide range of standard molecular and cell biology techniques, such as mammalian cell culture, nucleic acid isolation, and DNA / RNA / protein / chromatin extraction and analysis
• Ability to rapidly learn new techniques and to tackle experimental bottlenecks creatively
• Excellent problem-solving abilities and good understanding of basic statistics
• Excellent communication skills (oral and written)

To be successful at the Level B position you will need:

• PhD in revenant discipline (Biology, Genetics, Biomedicine, Bioinformatics, Computational Biology, …)
• Expertise in molecular biology and genomics technologies, particularly in chromatin structure, transcriptomics or epigenetics and/or integrative analyses of experimental datasets (e.g. 3D Genome, RNA-seq, ChIP-seq/CUT&RUN/Tag, DNA methylation, chromatin accessibility).
• Good publication record with evidence of independence
• Experience in mammalian cell culture
• Programming experience in at least one programming language (preferably R or Python) and experience with NGS data processing pipeline is highly desirable

Enjoy an outstanding career environment

The University of Adelaide is a uniquely rewarding workplace. The size, breadth and quality of our education and research programs - including significant industry, government and community collaborations - offers you a vast scope and opportunity for a long, fulfilling career.

It also enables us to attract high-calibre people in all facets of our operations, ensuring you will be surrounded by talented colleagues, many world-leading. Our work's cutting-edge nature - not just in your own area, but across virtually the full spectrum of human endeavour - provides a constant source of inspiration.

Our culture is one that welcomes all and embraces diversity consistent with our Staff Values and Behaviour Framework and our Values of integrity, respect, collegiality, excellence and discovery. We firmly believe that our people are our most valuable asset, so we work to grow and diversify the skills, knowledge and capability of all our staff.

We embrace flexibility as a key principle to allow our people to manage the changing demands of work, personal and family life.

In addition, we offer a wide range of attractive staff benefits. These include: salary packaging; flexible work arrangements; high-quality professional development programs and activities; and an on-campus health clinic, gym and other fitness facilities.

Learn more at: adelaide.edu.au/jobs

Your faculty's broader role

The Faculty of Health and Medical Sciences contains one of Australia's largest concentrations of leading health researchers, teachers and clinical titleholders. It's comprised of eight schools and a number of specialist disciplines, institutes and centres, variously focused on world-class research, and training the next generation of: medical doctors; surgeons; dentists; nurses; psychiatrists; psychologists; and other health professionals.

Learn more at: health.adelaide.edu.au

If you have the talent, we'll give you the opportunity. Together, let's make history.

Click on the ‘Apply Now’ button to be taken through to the online application form. Please ensure you submit a cover letter, resume, and upload a document that includes your responses to all of the selection criteria for the position as contained in the position description or selection criteria document.

Applications close 11:55pm, 15 October 2024.

The University reserves the right to close this advertisement before the closing date if a suitable candidate is identified.

For further information

For a confidential discussion regarding this position, contact:

Dr Joanna Achinger-Kawecka
Group Leader, SAiGENCI
E: joanna.achinger@adelaide.edu.au

You'll find a full position description and/or selection criteria below: (If no links appear, try viewing on another device)

The University of Adelaide is an Equal Employment Opportunity employer committed to providing a working environment that embraces and values diversity and inclusion. Female applicants, people with a disability and/or and Aboriginal and Torres Strait Islander people who meet the requirements of this position are strongly encouraged to apply. If you have any support or access requirements, we encourage you to advise us at time of application. 

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